• To date attention has been

  2024-03-30

  

  To date, attention has been directed towards new molecular targets in luminal phenotype (ER-positive), such as CDK4/6 and, to a lesser extent, androgen receptor (AR) pathways [8]. While the role of CDK4/6 has been elucidated and their inhibitors have shown a benefit in luminal BC, the role of AR in

• The AMP Activated Protein Kinase AMPK has evolved as

  2024-03-30

  

  The 5′AMP-Activated Protein Kinase (AMPK) has evolved as an important cellular sensor of reduced energy status that can subsequently phosphorylate its target proteins, slowing the rates of key biosynthetic processes and promoting energy producing pathways; for these reasons AMPK has been proposed as

• br Introduction AMPA receptors AMPARs mediate the

  2024-03-30

  

  Introduction AMPA receptors (AMPARs) mediate the majority of fast excitatory postsynaptic currents (EPSCs) in the Acarbose (Jonas, 2000). The brevity of EPSCs and rapid deactivation of AMPARs depend upon a short lifetime of synaptically released glutamate, estimated to be about 1 ms (Clements et

• br Introduction AMPA receptors AMPARs mediate the

  2024-03-30

  

  Introduction AMPA receptors (AMPARs) mediate the majority of fast excitatory postsynaptic currents (EPSCs) in the Pentamidine dihydrochloride (Jonas, 2000). The brevity of EPSCs and rapid deactivation of AMPARs depend upon a short lifetime of synaptically released glutamate, estimated to be about

• So far many independent studies have linked cholesterol meta

  2024-03-30

  

  So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential Apocynin levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013, Leduc et al., 2015,

• AdipoRon is an orally active synthetic

  2024-03-30

  

  AdipoRon is an orally active, synthetic small molecule that activates adiponectin receptor (AdipoR). It mimics the antidiabetic effects of adiponectin, exhibiting its effect through the activation of AMPK and PPARα pathways via AdipoR1 and AdipoR2, respectively (Fig. 2) [62]. AdipoR activation has r

• The rapidity of this specific immunosuppressive therapy sugg

  2024-03-30

  

  The rapidity of this specific immunosuppressive therapy suggests that it inhibits or apoptoses plasma cells. Most serum autoantibodies to AChR are produced by long-lived plasma cells residing in spleen and bone marrow. These terminally differentiated cells are resistant to most non-specific immunosu

• Consistent with the observation that mutations in the redox

  2024-03-29

  

  Consistent with the observation that mutations in the redox-partner binding site of P450c17 that reverse charge from basic to acidic (R347H, R358Q) cause 17,20-lyase deficiency (Geller et al, 1997, Geller et al, 1999), at least one POR mutation that changes a residue in the FMN domain from neutral t

• Axl which belongs to the Tyro Axl Mer TAM family

  2024-03-29

  

  Axl, which belongs to the Tyro-Axl-Mer (TAM) family of RTKs, has been reported to regulate a variety of physiological processes including cell survival, proliferation, migration and adhesion, through the activation of the phosphoinositide 3-kinase (PI3K)/V-akt murine thymoma viral oncogene homolog (

• br Autophagy in cancer br Phytochemicals

  2024-03-29

  

  Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cancer

• Along with the improvement of the cadmium

  2024-03-29

  

  Along with the improvement of the cadmium transport from roots to aerial tissues, as is required for phytoremediation, over-expression of PtoHMA5 also led to the excessive accumulation of cadmium in leaves that was harmful to plant growth and physiological performance. Thus, detoxification of the he

• In the last decade the

  2024-03-29

  

  In the last decade, the zebrafish has emerged as a valuable vertebrate model to systematically dissect the genetic underpinnings of both vertebrate heart development and function [8,9], as well as distinct cardiac diseases such as congenital heart disease [10], cardiomyopathies [11,12] and cardiac a

• br Material and methods br Results br Discussion Asparagine

  2024-03-29

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential OSU-03012 for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase i

• br Materials and methods br Results

  2024-03-29

  

  Materials and methods Results In order to evaluate changes in the amount of PKC-θ expressed by MEL cells at different stages of the cell cycle, we measured the level of the kinase in cells collected from cultures containing 90% of cells in the interphase or 80% cells synchronized at the metaph

• Once apoptosis has been initiated the HMGA proteins themselv

  2024-03-29

  

  Once apoptosis has been initiated the HMGA proteins themselves undergo marked changes in both the types and extent of their post-translational modifications (PTMs; review in [149,175]), some of which are likely correlated with alterations in chromatin structure. For example, the early stages of apop

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