• So far only few studies report about

  2021-10-21

  

  So far only few studies report about GAL in the visual system: GAL has been detected in the cornea of rat (Jones and Marfurt, 1998), mouse (Henken and Martin, 1992) and pig (Stone et al., 1988), and in the uvea of rat (Strömberg et al., 1987), pig (Stone et al., 1988) and cat (Grimes et al., 1994),

• The development of metabolic stable non peptidergic galanin

  2021-10-21

  

  The development of metabolic stable, non-peptidergic galanin agonists could be the basis to clinical diagnosis and treatment of tumors with high levels of galanin receptor expression like gliomas and pituitary tumors. As for gliomas, penetration of the blood brain barrier by the compounds might be p

• 3463 It has been reported that CD glioma

  2021-10-21

  

  It has been reported that CD133+ glioma stem 3463 are resistant to temozolomide (TMZ) therapy [155]. Dose dependent TMZ treatment of CD133+ cells enhanced activities of the Notch and SHh pathways [156]. Moreover, 500 μmol/L TMZ induced a significant upregulation of Gli1, HES1 and HES5 transcripts.

• br Materials and methods br

  2021-10-21

  

  Materials and methods Results Discussions The treated tannery effluent (both MF and MF+RO treated) was free from most of the organic and inorganic loadings as reflected from the values of COD, BOD, total kjeldahl nitrogen (TKN) and sulfides etc. Toxicity study of the effluent (both treated

• The inhibitory concentration of atrial natriuretic factor at

  2021-10-21

  

  The 50% inhibitory concentration of atrial natriuretic factor at midgestation and term are –7.4 ± 0.12 and –7.38 ± 0.11, respectively, demonstrating no gestational age dependency in the effect of atrial natriuretic factor on spontaneous contractile activity. Diethyl amine/nitric oxide starts to inh

• Glutathione transferases GST have been

  2021-10-20

  

  Glutathione transferases (GST) have been discovered in many tissues including the cornea of humans and several other mammals (Awasthi et al., 1980, Bilgihan et al., 2003; Gondhowiardjo and van Haeringen, 1993; Saneto et al., 1982, Sastry et al., 1995, Singh et al., 1985, Watkins et al., 1991). To da

• We have previously established the

  2021-10-20

  

  We have previously established the pharmacokinetic profile and effective dose of MNF in the rat [43] and demonstrated the effectiveness of MNF as an anticancer drug in Mometasone furoate australia and xenograft models [44]. Moreover, MNF was found to effectively block GPR55 signaling in tumor cells

• shows the hormonal and follicular growth profile of the woma

  2021-10-20

  

  shows the hormonal and follicular growth profile of the woman who ovulated in both cycles. In cycle 1, an LH surge occurred on day 17, when serum oestradiol concentration was 210.5 pg/ml and follicle diameter 17 mm. In cycle 2, ganirelix administration was continued until day 19 instead of until th

• We have previously designed an

  2021-10-20

  

  We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u

• One may ask whether induced loss through

  2021-10-20

  

  One may ask whether induced loss, through chemical or genetic perturbation for example, of an essential cellular factor represents regulated cell death or simple loss of the homeostasis needed for life. For example, deletion of the Mdm2 gene, or inhibition of the MDM2 protein, results in cell death

• br Materials and methods br Results

  2021-10-20

  

  Materials and methods Results To examine the apoptosis in FLS in vitro, we measured the number of filipin in early apoptosis (Annexin V+, 7-AAD−) and late apoptosis/necrosis (Annexin V+, 7-AAD+) using flow cytometry after incubation with or without stimulating Fas antibody. In the absence of

• To evaluate the role of

  2021-10-20

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on apigenin progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B),

• Interestingly evidence has emerged recently that

  2021-10-20

  

  Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli

• br Introduction Ovarian cancer patients have the

  2021-10-20

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer p53 pathway with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation i

• Recently the toxicity of TBT was demonstrated at the vascula

  2021-10-20

  

  Recently, the toxicity of TBT was demonstrated at the vascular level in animal models (Nath, 2008), and the results obtained so far suggest that TBT may be a potential risk factor for cardiovascular diseases. TBT is capable to alter the coronary vascular reactivity to estradiol (dos Santos et al., 2

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